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The role of oxidative stress also seems to be a key causative mechanism, since the use of an antioxidant reduced the phenomenon (14).
The role of oxidative stress also seems to be a key causative factor clinically because the use of an antioxidant reduced the phenomenon in both the studies (51).
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Soluble vascular endothelial growth factor receptor 1 (also know as soluble fms-like tyrosine kinase [sFlt]-1) is a key causative factor of preeclampsia.
Excessive nitrogen loading is a key causative agent for accelerating primary production or eutrophication (Nixon 1995; Paerl 1997).
Subsequently, it is commonly thought that the breakdown of the BBB is a key causative factor of sepsis-associated delirium [ 6- 8].
Overcrowding in prisons remains a concern in both developed and developing countries, and is a key causative factor for a myriad of other problems which ultimately turn these custodial settings into fertile breeding grounds for infectious diseases such as AIDS, hepatitis, syphilis, gonorrhoea and tuberculosis.
The efficacy of species immune responses to Batrachochytrium dendrobatidis the causative agent of the disease is proposed to be a key factor in determining disease outcome (Rollins-Smith et al. 2002; Savage and Zamudio 2011; Woodhams et al. 2007).
These findings suggest that the dysfunction of the p53 could be a causative event leading to the autophagy, and that p53-DRAM signaling might be a key target for drug development and anti-autophagy therapy.
Constitutive activation of β-catenin-dependent gene expression is almost certainly a key causative event in the genesis of colon and some other cancers.
Porphyromonas gingivalis, a gram-negative asaccharolytic bacterium, has been recognized as a key causative microbe in the pathogenesis of destructive chronic periodontitis.
Given its high prevalence in halitosis subjects, the Gram-positive strictly anaerobic bacterium S. moorei is considered as a key causative agent of halitosis [ 22- 25].
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