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Using expressed protein ligation, a Src ATP conjugate was produced and shown to be a high affinity ligand for the Csk tyrosine kinase.
Grb10 was first found to be a high affinity interacting protein with IR in vitro (Liu and Roth, 1995).
The antagonistic ability of CGP12177 itself was then investigated and was found to be a high affinity partial agonist at all three turkey β-adrenoceptors (Figure 7, Tables 2 4).
In addition to these targets, the β-carboline alkaloid, harmine, has recently been reported to be a high affinity inhibitor of DYRK1A kinase activity [16], [17], suggesting that harmine, and possibly other β-carboline derivatives, could alter tau phosphorylation.
XtrD has a high affinity for xylose, and may be a high affinity xylose transporter.
The simplest form of such a drug would be a high affinity, high selectivity synthetic ligand for the pathogenic BCR coupled to an appropriate toxin.
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CTR1 is considered to be a higher affinity copper transporter compared to CTR2.
TPR2A is a high affinity HSP90-binding domain, whereas TPR1 and TPR2B bind the HSP70 C-terminus with moderate affinity22,24.
Lehmann, J.M. et al. An anti-diabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ.
LNA is a high affinity nucleotide analog, nuclease resistant and elicits minimal toxicity.
It has been reported that ovarian cancer G protein-coupled receptor 1 (OGR1) is a high affinity receptor for SPC, and its closely related homologue GPR4 is a high affinity receptor for SPC with low affinity for lysophosphatidylcholine (LPC).
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