Based on much evidence, though, a CM with the above characteristics appears to be a heterogeneous entity and the obvious risk is that its definition may be extended to include a variety of different clinical entities.
However, it has been recently suggested that the checking category could be a heterogeneous entity, i.e., that some symptoms could be associated with one dimension and the others with other dimensions [ 25].
Low-grade squamous intraepithelial lesion is a heterogeneous entity that is composed of different human papillomavirus subtypes and prevails in younger women (<40 years old).
DLBCL not otherwise specified (referred to henceforth as DLBCL) is a heterogeneous entity in terms of clinical presentation, genetic findings, response to therapy, and prognosis.
Because ARDS is a heterogeneous entity, previous studies have striven to individualize subgroups of patients based on the risk factors involved [2], the presence of diffuse alveolar damage or not on lung histological analysis [3, 4], the presence of direct or indirect lung injury [5] or, more recently, by defining subphenotypes using latent class analysis [6].
Pre-diabetes is a heterogeneous entity.
Head and neck squamous cell carcinoma (HNSCC), which includes a variety of primary sites in the upper aerodigestive tract, is a heterogeneous entity.
Breast cancer is a heterogeneous entity, and the prognostic importance of intrinsic subtype has been extensively studied by gene-expression profiling.
Each psychiatric condition is a heterogeneous entity: for example, bipolar disorder is one disease composed by very opposite phases and symptoms, if we consider maniac and depressive episodes.
This observation suggests that metabolic syndrome is a heterogeneous entity and, when used as a dichotomous outcome, may mask the differential associations with health risk.
While TS is a heterogeneous entity [ 8], the combination of associated comorbidities with prominent and severe SIB may raise questions about the diagnosis.
