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This appears to be a generalized effect of IL-4 insofar as similar inhibition was also observed in fibroblasts.
Importantly, this phenotype was not restricted to hippocampal neurons and it was also observed in layer V cortical neurons, suggesting that the reduction in dendritic arborization might be a generalized effect of miR-9 loss of function.
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To further investigate whether the increase in the density of VGAT and VGLUIT2 terminals is restricted to the terminals apposing/contacting GnRH neurons only or is a generalized effect in the area in close vicinity of GnRH neurons, we counted the total number of VGAT and VGLUT2 positive terminals in the close vicinity of GnRH neurons.
These data indicate that endothelial dysfunction and activation of the endothelin system in response to air pollutant exposure, given a sufficient PM dose, is a generalized effect rather than being restricted to a subset of sensitive individuals.
We have now extended our morphological analysis finding that the dendritic defects in miR-9 sponge expressing neurons are not restricted to hippocampal neurons but are also observed in cortical neurons (layer V), suggesting that this is a generalized effect of miR-9 loss of function.
It is unclear whether the apparent small reduction in the odds ratio for these various types of childhood cancer is a generalized effect of breastfeeding or whether it reflects some systematic bias in the majority of studies that have investigated the question.
Although the lower BOLD response to cocaine appeared to be a generalized and nonspecific effect, several brain areas of acutely and repeatedly treated rats did not show differences in BOLD signal intensity (namely, the dorsal prefrontal cortex, cingulate, and somatosensory cortex).
Interestingly, under these conditions, RelA mRNA levels remained unchanged, suggesting that the Tat-mediated increase in RelB was not a generalized effect of Tat on NF-κB subunits (Figure 1).
Presently observed changes in the topography in the whisker and the neck region are unlikely to be due to a generalized effect of administration of anaesthetics.
"[The result] suggests that this effect appears to be a generalized response to global mortality concerns rather than a localized reaction to a specific mortal threat.
The observed association in several brain areas between disordered microstructure and the SF36 MCS could be due to a generalized effect of long-standing DM on the brain, which is also manifested as a reduction of general mental well-being and may not solely be related to dysfunction of the visceral sensory system.
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