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To further examine whether activation of Nrf2 could possibly be a future approach for treating STING-dependent inflammatory diseases, we used immortalized fibroblasts from three patients who harbor gain-of-function mutations in STING and who are diagnosed with SAVI19.
This intriguing finding must be demonstrated in other settings, but this could be a future approach to settings where inflammation is a key factor and infection comes into play later, such as trauma and extracorporeal circulation.
Systematic quantitative screening of genetic diversity on the RNA level in multiple individuals and tissues will be a future approach in the elucidation of the molecular mechanisms that regulate gene expression.
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On the basis of an understanding of brain mechanisms that lead to overeating, powerful neuroimaging protocols could be a future clinical approach to allow individually tailored treatment options for patients with obesity.
Thus, reducing the load of inflammatory triggers may be a future general approach in AKI.
The Texas appellate court has held that the facts of the original crime – which have to be proven at the preceding "guilt-innocence" stage of a trial – may be sufficient to demonstrate that the defendant could be a future danger, an approach that empties the sentencing hearing of any significance.
This will be a future application of our approach.
Furthermore, modulating BubR1 activity may be a promising future approach to tailored therapy for ovarian cancers.
Our results also indicate that adjuvant immunotherapy may be a reasonable future approach for the treatment of ascites.
(5) Clinical strategies designed to counteract miR-125b-mediated effects could be a valuable future approach to the management of ER+ breast cancers that develop resistance to AI endocrine therapy.
We are, however, preparing a future approach using parsimony and branch lengths to reconstruct ancestral genomes (Royer-Carenzi M, Didier G, personal communication).
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