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In other cancers, PLK1 has been reported to be a functional target of miR-100.
Moreover, the mitochondrial respiratory chain complex I was recently reported to be a functional target for NOX4 (8).
Peterson et al. [ 22] evaluated allelic variant of ROCK2 in women with preeclempsia and proposed that ROCK2 could be a functional target for the regulation of preeclempsia.
Taken together, major functions of Bcl11b in postnatal hippocampal development, that is, regulation of progenitor cell proliferation as well as neuronal cell differentiation are recapitulated in Dsp mutants suggesting Dsp to be a functional target of Bcl11b.
These results showed that Rab35 has an opposite effect on HeLa cell migration, in comparison with miR-720, indicating that it may be a functional target of miR-720 in HeLa cells.
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Occludin is a functional target of the E3 ligase Itch [37].
The lower the P is, the higher the chances that the 5' UTR is a functional target.
Moreover, increasing evidences also suggest that p53 is a functional target of UCP2 [ 14].
These results suggested that VLDLR is a functional target of miR-135a-5p miR-135a-5p miR-135a-5p
However, there is increasing evidence that p53, the main guardian of genomic integrity is a functional target of UCP2.
Either EMSA or DNase I footprinting is required to determine whether it is a functional target for PhoP-specific binding.
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CEO of Professional Science Editing for Scientists @ prosciediting.com