Sentence examples for be a functional null from inspiring English sources

However, in the food race assay slo-1 (js379), which are predicted to be a functional null for the channel [39] showed a similar navigational impairment to wild-type animals in the presence of ethanol (Figure 8A) and reduction in locomotory speed on food race plates (Figure 8B).

The prokr2 Brdm1 allele (abbreviated here to m) was confirmed by radio-ligand binding assay to be a functional null (Prosser et al., 2007).

It is likely to be a functional null; no Ptprq protein is detectable in the hair cells of homozygous Ptprq CAT-KO mice (Goodyear et al., 2003).

The excision deletes 1534 bp including the predicted translation start site and the first 102 codons of CLN3 (see Supplementary Material, Fig. S1) and is therefore likely to be a functional null.

Note that vps33 car is a hypomorphic allele with partial loss-of-function, while vps33 R281A is a functional null with total loss of function.

This allele is a functional null allele with respect to its ability to interact with, phosphorylate, or promote proteosomal degradation of PER proteins [9].

Even though the repeat expansion mutation is a functional null mutation, few conventional mutations have been identified at this locus, largely due to the clinical laboratory focus on the repeat tract.

We compared the Egfrf24 mutant phenotype with another allelic combination, Egfrts1a/ Egfrts4 (Egfrts), which is a functional null at 29°C (Kumar et al., 1998).

Recent studies identified an ENU-induced allele of Shroom3 called Shroom3 m1Nisw and embryos homozygous for this allele phenocopy homozygous Shroom3 gt ROSA)53sor embryos suggesting that this is a functional null allele (Fig. 1B) (Marean et al., 2011).

In Amt −/− mice, overall GCS activity was effectively ablated being below the detection level of the assay (0.01 nmoles of CO2 formed/gram protein/h), consistent with the Amt − allele being a functional null (22) (Fig.  4).

Analysis of mRNA levels in homozygous Dynll1 GT/GT embryonic tissue demonstrated highly significant downregulation of Dynll1 expression, consistent with it being a functional null allele (supplementary material Fig. S6).