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The pea (Pisum sativum) gene PEAM4 seems to be the closest to AP1 in function and has been suggested to be a functional homologue of AP1 [ 23] based on similar expression pattern and floral phenotype.
NanoRNase is believed to be a functional homologue of E. coli oligoribonuclease (Orn), which is essential for cell viability [ 37].
However, it has been suggested that the UV-DDB complex (containing DDB1 and the GG-NER-specific DDB2) might be a functional homologue of Rad16/Rad7 [ 63].
Another mammalian MYST protein, HIV tat-interacting protein 60 (Tip60), seems to be a functional homologue of the yeast protein Esa1 [ 22], which is the only essential HAT for yeast viability, playing a role in cell cycle progression [ 23].
Based on amino-acid similarity, Rik1 is thought to have an intertwined three β-propeller cluster and to be a functional homologue of DNA-damage binding protein 1 (DDB1).
Though the matching sequence comes from a glutathione S-transferase, which is unlikely to be a functional homologue of Plin2, an exact match of 9/13 residues between these two peptides means they are statistically likely to fold the same, as an α helix as previously described.
Similar(54)
Rik1 contains a WD40 domain and is a functional homologue of human DDB1 (UV-damaged DNA binding protein 1) (Horn et al., 2005).
Mouse KC is a functional homologue of human IL8.
This is a functional homologue of HLA-E, which presents leader peptides of MHC class I molecules to the inhibitory NK receptor CD94/NKG2A [31].
A lack of apparent phenotypes is also characteristic for deletions of the riboregulator 6S RNA, which is a functional homologue to Rsd.
CDKF 1 is a functional homologue of yeast CAK1 that regulates CDC28/CDK activity during meiotic differentiation [186] through the kinase IME2/PIT1, which stabilizes Sic1p, the functional orthologue of human p27KIP1 [187].
More suggestions(15)
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be a functional cpGTPase
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