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This feature is thus likely to be a functional convergence between amoebozoan NdkM and vertebrate Nme4.
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As is the case for Has-tsfgr1, it is difficult to infer whether this is due to sequence homology, or whether it is the result of a functional convergence on a motif that provides a particular structure and/or function.
Thus, in addition to a glomerular organization of the ONs, these features might be part of the ground pattern of Mandibulata or a functional convergence.
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Some of these signal sequences highlight an apparent paradox: they are encoded, by definition, by orthologous DNA segments but they are, given their striking divergence, examples of what can be called functional convergence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com