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Thus, PI3K and/or mTORC1 pathway activation appears to be a frequent pathogenic feature of all endometrial carcinoma subtypes, not only of type I tumours.
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We suggest that PI3K-mTOR pathway activation and TP53 inactivation play different roles in the initiation of type I and type II endometrial cancer initiation but that combined signalling pathway alterations in both PI3K and/or mTORC1 and p53 are a frequent unifying pathogenic feature of late stage tumours of both subtypes.
Aneuploidy is a frequent occurrence in pathogenic isolates of Candida albicans isolated from human hosts.
They could be applied for the protection against pathogenic microorganisms as S. pneumoniae which is a frequent nasopharynx colonizer.
Giardia lamblia (syn G. intestinalis, G. duodenalis) is the most common pathogenic intestinal parasite of humans worldwide and is a frequent cause of endemic and epidemic diarrhea.
Author is a frequent customer.
This is a frequent error.
It is a frequent sound.
"I am a frequent traveller.
You're a frequent karaoke performer.
Spraying for cockroaches is a frequent chore.
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