Sentence examples for be a frequent mutation from inspiring English sources

Although L110P may be a frequent mutation, especially in Japanese patients, there were no marked differences in the clinical picture between L110P/E148Q and E148Q alone.

The BRCA1 c.3700_3704del5 mutation is a frequent mutation in Germany [ 17, 21].

p53 is a frequent target for mutation in human tumors, and mutant p53 proteins can actively contribute to tumorigenesis.

Ras is a frequent target for mutation in human cancers.

In broader terms, one has to note that many of the tumours associated with PJS, including GI and gynaecologic malignancies are also those where KRAS is a frequent target of mutation.

The CTCF anchor regions we identified are conserved across species, influence gene expression, and are a frequent site of mutations in cancer cells, underscoring their functional importance in cellular regulation.

FLT3, the cognate FL receptor, is a frequent target for mutations in leukemia.

R462Q is a frequent and well-characterized mutation and homozygosity for the rare allele reduces the activity of RNase L by 3 fold [13].

However, the p53 gene is a frequent target of missense mutation rendering it unable to recognize the p53 consensus binding sites therefore loss of transcriptional function of p53 in cancers [ 47].

However, estrogen receptor mutation is a frequent event in BRCA-linked breast cancer, suggesting that tumorigenesis caused by BRCA gene mutation affects pathways other than those controlled by the estrogen receptor.

First, we show a 20.6% mutation rate of the PIK3CA gene in breast cancer, indicating that PIK3CA mutation is a frequent genetic alteration in breast cancer.