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Phosphorylation of p53 at Ser has been shown to be a frequent modification in tumours (Minamoto et al, 2001).
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The broad appearance of the band points to the glycosylated status of the protein, which is a frequent modification of serpentine receptors (Fig. 2B).
H3K4me1 is a frequent histone modification in macronuclei of Tetrahymena as well as in nuclei of S. cerevisiae and human [ 29, 32].
Protein S-palmitoylation is a frequent post-translational modification in eukaroytic cells and mostly mediated by members of the DHHC (Asp-His-His-Cys) protein family.
For example, says Tomer, phosphorylation is a frequent post-translational modification involved in cell signaling, but even during active signaling, phosphorylation may occur at only one spot on a protein and upon less than 5% of that particular protein population for less than one minute.
A frequent modification occurring to silicone oil is emulsification.
Epigenetic modification is a frequent mechanism of inactivation of tumor suppressor genes in colorectal cancer [ 16].
Epigenetic modification is a frequent mechanism of inactivation of tumor suppressor genes in lung cancer including promoter hypermethylation and histone deacetylation [ 21].
Among these seven missense mutations, six mutations were predicted by SIFT and PolyPhen 2 to have a deleterious effect on the protein function (Table S3), suggesting that there is a frequent disruption of the chromatin modification processes in the pathogenesis of ESCC.
Liposomal encapsulation is performed with no chemical modification, leaving no residual background activity of the molecule, which is a frequent problem accompanying caging of biological molecules.
The carboxy termini of proteins are a frequent site of activity for a variety of biologically important functions, ranging from post-translational modification to protein targeting.
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