Sentence examples for be a frameshift mutation from inspiring English sources

This deletion is considered to be a frameshift mutation causing the loss of the function of the P11 allele.

Another type of point mutation that can lead to drastic loss of function is a frameshift mutation, the addition or deletion of one or more DNA bases.

Three of the complementing dpolv mutants in exon 11 are missense mutations but the complementing mutant dpolv105A is due to a nonsense mutation, and dpolv6 in exon 15 on the other side of the PIGSFEAST exon is a frameshift mutation which generates a stop codon.

In contrast, the dominant mutation identified in a Dutch pedigree is a frameshift mutation in the final exon.

Five of the point mutations lead to nonconservative amino acid changes, and the sixth is a frameshift mutation.

In total, seven of 47 tumors (15%) revealed mutations, of which six were missense mutations and one was a frameshift mutation.

The CC insertion is a frameshift mutation located in exon 8 of GRN, introducing a premature stop codon 27 amino acids after the insertion site (Ile256IlefsX27).

The first (p.P177fs) is a frameshift mutation caused by the deletion of cDNA cytosine 530, the second (p.P411del) is a proline deletion due to the c.1232-1234delCCT.

The c.649_650InsC (p.P217fsX7) mutation is a frameshift mutation, which generates a different sequence starting at position 217 and introduces a premature stop codon at position 224, generating a truncated protein with only 223 amino acids.

It was a frameshift mutation and resulted in a premature stop codon leading to a truncated protein (Pro160Cysfs*14) with a predicted lack of both the C3HC4 RING motif and MKRN-specific Cys His domain.

Among 9 identified causal QTL mutations, 2 are missense mutations, 2 are non-sense mutations, and 1 is a frameshift mutation demonstrating that these classes of overt coding sequence mutations contribute to QTL phenotypes, at least for QTL of large effect size [ 2].