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0 1 D Founder effect, bottleneck "Um, I guess that would be a founder effect I think, or a bottleneck.
Therefore, another possible explanation for the cpDNA dimorphism might be a founder effect followed by limited gene flow during late Pleistocene glaciations and interglacial periods.
Up to 10% of cases are attributable to BRCA1 and BRCA2 mutations and conceivably, there could be a founder effect in the Acadian region.
With regard to genetic predisposition, as Cajuns are a known founder population, it is possible that there could be a founder effect for hereditary CRC in the population.
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A likely reason for a preponderance of a disease in a specific population is a founder effect.
This is consistent with Africa being the ancestral region of A. aegypti and suggests there has been a founder effect in its colonization of Southeast Asia.
Our identification of a common haplotype among the majority of HOXB13 G84E carriers indicates that there is a founder effect with a higher frequency of the mutant allele in Nordic populations.
Hence, if there is a founder effect in the Cajun population, this may explain why CRC rates are disproportionately high compared with the state of LA in whites as opposed to African Americans.
The homozygous mutation R527C associated with HGPS has been recently reported in another two pedigrees from Southern China [ 25, 26], considering the respective frequencies of the diseases, such events for Southern Chinese population are just fortuitism or whether there is a founder effect or not needs further study.
Other possibilities are that they are older in evolutionary terms, and thus have had more time to become widespread, or that we are seeing a founder effect in some populations with subsequent spread following human migration patterns.
Molecular studies of TE copies from high and low occupied sites [ 14] strongly indicated that the most reliable explanation of the observed bimodal distribution is that a founder effect followed by genetic drift occurred during the colonization process.
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