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We propose that reversal of advanced heart failure is possible by targeting the defects in SR calcium cycling, which may be a final common pathway for the progression of many forms of heart failure.
45– 49 A proinflammatory cytokine cascade may be a final common pathway by which IRIS inflammation occurs.
The inflammatory processes and AA might be a final common pathway in the pathogenesis of AD (formation of amyloid plaques).
Therefore, autonomic imbalance may be a final common pathway to increased morbidity and mortality from a host of conditions and diseases, including cardiovascular disease [ 4, 5].
Genetic and neuropathological studies demonstrate that numerous causative factors act through a similar pathophysiological mechanism, and autism appears to be a final common pathway of behavioral expression for many disorders [ 39– 41].
It is notable that in all these diseases, increased stathmin is a gain-of-function brought about by different genetic mutations, demonstrating that increased stathmin could be a final common pathway to disease pathogenesis, with other factors defining which motor neuron type is affected.
Similar(53)
Ending up in trouble with the law has always been a final common pathway for some portion of psychologically injured veterans".
How best to serve this population remains a subject of debate, because autism is a "final common pathway" diagnosis, meaning children arrive here from different points of origin, are troubled by a wide variety of issues and respond to different strategies.
Perhaps HSP is a "final common pathway" of infection with multiple organisms including Bartonella.
E2F1 is a final common regulator for G1/S cell cycle transition (Cam & Dynlacht, 2003).
Tooth loss is a final common pathway for oral diseases and is an important oral health indicator.
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