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Reasons for the retrograde, dynein mediated transport of MID1 could either be a feedback regulation at the outgrowing tip in order to avoid an excess of microtubule-stabilizing factors which would perturb the delicate equilibrium of microtubule dynamics.
Therefore there might be a feedback regulation between androgen and GNMT.
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Furthermore, the expression of many cellulase and hemicellulase genes is shown to be under a feedback regulation mechanism that functions under conditions in which the capacity of the cells to fold and secrete proteins is limited and transcriptional down-regulation is required to reduce the amount of secreted protein produced [ 16].
The basic idea underlying our modeling was that a feedback regulation of Per1 or Per2 transcription by PER1/2 could be the basis for the observed phase difference between Per1 and Per2.
Since the message levels were analyzed in fully differentiated DCs, this could be due to a feedback regulation at the transcript level or differences in the half-life and/or the translational rates in the two DCs.
We suspect that this effect may be attributable to a feedback regulation loop of PI3K/Akt via the adaptor protein, IRS-1 and PI3K p85 regulatory subunit.
These traits indicate that the association of MKP3 with ERK also could be involved in a feedback regulation that eventually shifts ERK activity to the nucleus.
6-BA is an iP type CK, and exogenous 6-BA application repressed the transcriptions of adenylate IPT genes, whereas the tRNA IPT genes were upregulated by a feedback regulation.
The possible explanation might be that there was a negative feedback regulation loop in the downstream of aPKC ι signal pathway.
The induction at 24 h of GID1A, coding for the most abundant GA receptor in dry and imbibed seeds, is possibly due to a feedback regulation triggered by changes in the ABA/GA ratio, as previously suggested [ 58].
One obvious candidate for that is a negative feedback regulation by an antagonist of the diffusible factor for cell-cell communication, as indicated in the model of Bolouri and Davidson [ 8], although such additional control is dispensable for the community effect.
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