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7 The common variant (Q141K, rs2231142) of ABCG2 is proven to be a dysfunctional variant by in vitro functional studies.
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You can be a dysfunctional member of Congress, but not a dysfunctional governor.
"We cannot be a dysfunctional family".
Or will it be a dysfunctional mess?
As the proteins encoded by these genes form an evolutionarily conserved complex that could be functionally impaired by a dysfunctional variant in any one of the genes, we evaluated them as if they constitute a single candidate susceptibility gene.
Our data support previous observations primarily made in vitro that the G551D variant is a dysfunctional channel that is properly processed and that the delta F508 variant undergoes biosynthetic arrest at the level of the ER.
Even though an amino acid is changed as a result of the sequence variation, this study does not clearly show, but does support, a dysfunctional variant.
"But there is a dysfunctional supply.
Congress is a dysfunctional mess.
He was a dysfunctional director.
"It's a dysfunctional system," he says.
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