Sentence examples for be a driver mutation from inspiring English sources
The program gave each of the 963 DNA changes a score between zero and one, with zero meaning a likely driver and one meaning not likely to be a driver mutation.
Gene maximum multiplicity serves as a measure of a gene's systemic occurrence and hence a gene's potential to be a driver mutation rather than a passenger mutation.
The NOTCH1 mutation (M1615I) occurred in the NOD domain and is likely to be a driver mutation, since it was previously reported at the same nucleotide position in the COSMIC database.
However, because EGFR mutation is considered to be a driver mutation for carcinogenesis, the presence of another driving factor to induce tumor cells with wild-type EGFR would be necessary, suggesting that this event would be very rare.
Recently, Gu et al. found a fusion of the ROS1 gene with the FIG gene in 2 out of 23 patients (8.7 %) with cholangiocarcinoma; the authors suggested that this could be a driver mutation, because it confers transforming activity to bile duct cells and can be effectively blocked with an ROS1 tyrosine kinase inhibitor [ 17].
suggesting that the fusion gene is a driver mutation, not just a passenger mutation.
However, although it is rare, we believe that the somatic mutation of BAP1 is a driver mutation of ESCC, at least in some cases, including the current one.
Smad3 missense mutation was identified in HNSCC at a very low frequency, but it remains to be determined if this is a driver mutation [ 43].
This implies that ALK fusion itself exerts very strong driving forces for tumorigenesis, in other words, that ALK fusion is a driver mutation, not just a passenger mutation.
It is hypothesised that FGFR1 amplification is a driver mutation (Weiss et al, 2010) and subsequently should therefore be seen early on in small tumours.
However, as a final test of CNA being a driver mutation, we present a context-specific analysis: a NEA of individual CNAs versus the filtered SNV gene sets of the same cell line (Table S7 in Additional file 1).
