If PVD is primarily a downstream result of the activation of the inflammatory-coagulation cascade in the lung, then, the reason it is associated with mortality in ARDS may be because it reflects the severity of the underlying inflammatory process.
The co-chair of the Close the Gap campaign, Mick Gooda, has also called for a justice target, saying that criminal behaviour is often a "downstream" result of poor education and employment options.
The role that microtubule stability plays in axon degeneration and, in particular, whether microtubule breakdown is a downstream process resulting from activation of proteolytic cascades or has a more active role in the onset of degradation, is currently unclear.
Because Akt is a downstream effector of PI-3K, these results indicate that activation of both Akt and p44/42 MAPK, but not p38 MAPK, is required for SDF-1 α-dependent invasion of CD26-expressing T cell lines.
These data suggest that elimination of tumor cell populations with stem-like traits through ERK5 inhibition might be a result of downstream IL-8 repression.
It is hypothesized that the aforementioned disruption in the oxidative stress pathway is the downstream result of an imbalance in intracellular calcium and magnesium, which results in high intracellular calcium and low intracellular magnesium [19], [20].
As the action of denosumab impacts only this single critical element of the bone morphogenic units, all levels of markers, electrolytes, cytokines, and changes in BMD can be considered downstream results of RANKL inhibition.
As a result, another 3' splice site is selected downstream, resulting in a 10 bp deletion in the RPT5b mRNA.
The proliferative effects mediated by GPR55 are thought to be a result of ERK activation and downstream expression of c-Fos.
The excess of [A→G] over [T→C] substitutions downstream to the 3'end might be a result of the non-template strand being signaled for TCR or due to the continuation of transcription downstream to the 3'end [ 39] or because of other processes that are not induced by transcription per se [ 40].
