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Therefore, the tumourigenesis of GCA is different from EA and DGA, and thus GCA should be a distinct pathological entity.
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Pleomorphic Lobular carcinoma in-situ (PLCIS) is a distinct pathological entity within LCIS and there is no consensus regarding surgical margins or the need for adjuvant treatment to prevent recurrence.
Perineural invasion is a distinct pathological entity that can be observed in the absence of lymphatic and vascular invasion [ 9].
Perineural invasion is a distinct pathological entity, yet less commonly observed than lymphovascular invasion in CRC patients (Washington, 2008).
PNI is a distinct pathological entity that can be observed in the absence of lymphatic or vascular invasion, and it is associated with aggressive tumor behavior and worse clinical outcome [ 90].
Previously classified as a subtype of multiple sclerosis, NMO is now considered to be a distinct clinical, pathological, and immunological entity [ 1].
It is believed that vascular dementia is a distinct clinical and pathological entity from Alzheimer's dementia, Lewy body dementia, or fronto-temporal dementia, although elements of vascular disease may be present in all of these conditions.
Negative symptoms might be differentiated from positive symptoms by a distinct pathological process.
This has challenged our understanding of human evolution and created much debate about whether H. floresiensis was a distinct species or a pathological example of modern humans [ 28- 30].
Whether the loss of the neurites themselves is secondary to the loss of AV or reflective of a distinct pathological mechanism requires further study.
The establishment of autism as a distinct pathological condition has certainly improved the lot of countless patients and their family members, but, as Donvan and Zucker relate, the road has been far from smooth.
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