Fifthly, since there is no information at present on whether the SNP in the ANK3 gene (rs10994336) is a direct functional variant or a tagging SNP, which may reflect the effect of another, as yet unknown, variant which has a direct functional effect on both risk of BD and visual sustained attention.
In this study, we demonstrated that there is a direct association between genetic variants of the TL1A gene and the induction of TL1A in Jewish CD patients.
Thus, the associations between the NEDD4L rs4149601 and rs2288774 polymorphisms on the one hand and P-renin and Nt-proANP on the other, are likely to be secondary to genetically mediated enhancement of tubular sodium reabsorption rather than being a direct effect of the genetic variants on renin and Nt-proANP secretion.
This high number of misclassified rare variants is a direct consequence of Illuminus' within SNP, across sample, approach to genotype calling.
Since none of the other common allelic combinations (10/2 and 9/3) conferred risk for ADHD, we concluded that either the 10/3 haplotype tags a functional variant that occurs on this haplotype background (i.e. neither of the markers studied so far are functional), or that there is a direct interaction between two functional variants.
These results provide a biologically plausible mechanism for the increased risk of CAD conferred by these LTA4H variants since LTB4 is a direct product of the reaction catalyzed by this enzyme and is a potent chemotactic molecule that mediates the recruitment of neutrophils, monocytes, and other leukocytes to sites of inflammation, including the arterial wall of atherosclerotic lesions.
This is a direct command.
A direct tax on sugar would be a variant of other, more targeted taxes on sugars that have been discussed globally for years, especially taxes on soft drinks, with Mexico being the most recent example of large-scale implementation.
Be a good English variant supporter.
If an observed genetic association is true, then it implies that either the investigated variant is causal (direct association) or there is a causal variant in linkage disequilibrium with the investigated one in its neighborhood (indirect association).
