"I do not believe minorities will be a direct target under the Trump administration, as this would immediately be under the spotlight.
It will be intriguing to test whether cGAS itself may be a direct target of caspases.
Recent studies additionally suggest that trigeminal branches innervating the meninges can have extracranial collaterals which could be a direct target for therapeutic interventions such as ONB [17].
Hence, Sox9 appears to be a direct target of Notch1.
These observations suggest that MMP13 is likely to be a direct target of Ets1.
The C. neoformans laccase Lac1 may also be a direct target of Pmt4.
We tested a possibility that tubulin itself could be a direct target.
Survivin has been shown to be a direct target of FoxM1 in cell lines and in primary colon cells [28], [30], [34].
In the embryonic trachea, data suggest that DEcad may be a direct target of Rab11-mediated trafficking, with regulated Rab11 function regulating cell intercalation [45].
Neither LKB1 nor AMPK is thought to be a direct target of metformin, and the key upstream point of interaction is not known.
The latter has recently been shown to be a direct target of PPARβ/δ [47] and to be upregulated in psoriasis [48], thereby corroborating our findings.
