Sentence examples for be a direct substrate from inspiring English sources

It has also been revealed to be a direct substrate of IR in vitro and becomes tyrosine phosphorylated upon insulin stimulation in vivo (Delahaye et al., 2000).

STAT5B (signal transducer and activator of transcription 5B) has been demonstrated to be a direct substrate for IR both in vitro and in vivo (Chen et al., 1997; Sawka-Verhelle et al., 1997; Storz et al., 1999; Sawka-Verhelle et al., 2000).

We therefore tested whether SU VAR 3 9 might be a direct substrate of the JIL-1 kinase.

Among the five canonical Notch ligands in mammals, Dll3 lacks a lysine residue in the cytoplasmic domain for ubiquitination, suggesting that it might not be a direct substrate of the E3 ubiquitin ligases.

It is possible that α-tubulin may be a direct substrate of ICP0's E3 ligase activity, but the history of ICP0 research suggests that such speculation is premature.

As, shown in Fig. 5B and C, βNAC was very efficiently cleaved upon activation of caspases by cytochrome c or granzyme B. Interestingly, granzyme B also produced an additional βNAC cleavage product, suggesting that the latter may also be a direct substrate for this granzyme.

Altogether, these data indicate that PKM2 is a direct substrate of JNK1.

Subsequent work demonstrated that Yorkie is a direct substrate of Warts and that Yorkie promotes cell proliferation and growth.

The MAPK-activated protein kinase 2 (MK2) is a direct substrate of the p38 MAPK α-and β-isoforms [18].

Therefore, Bcl-w binds to Akt and is a direct substrate of Akt; however, this binding does not alter the activity of Akt on other substrates.

Therefore, future investigation of the direct phosphorylation of NS5A by MEK would help determine whether the viral NS5A is a direct substrate for this cellular kinase.