Sentence examples for be a direct functional from inspiring English sources
Moreover, in vitro and in vivo data demonstrate that treatment with thapsigargin, which activates the UPR via disturbance of calcium homeostasis, is accompanied by increased tau phosphorylation, suggesting there may be a direct functional connection between UPR activation and tau phosphorylation.
To further examine whether PLD1 is a direct functional target of miR-638 in GC cells, we performed a series of functional restoration assays.
Recently, cystatin C was identified as a novel substrate for MMP2 in cell-based proteomic analysis, suggesting that there is a direct functional link between MMP2 and cystatin C [40].
Fifthly, since there is no information at present on whether the SNP in the ANK3 gene (rs10994336) is a direct functional variant or a tagging SNP, which may reflect the effect of another, as yet unknown, variant which has a direct functional effect on both risk of BD and visual sustained attention.
The difference may be that our study is a direct functional assessment of receptor-mediated actions versus a ligand-binding activity, which does not necessary reflect biological activity.
A transcriptionally active β-catenin (unphosphorylated on Serines 33 and 37 as well as Threonine 41) [ 36] is a direct functional readout of Wnt/β-catenin signaling.
An alternative avenue of investigation has been to assess whether there is a direct, functional relationship between epigenetics and genetics at particular risk alleles.
Taken together, these data suggest that PTEN is a direct functional target of miR-21, and its expression is regulated by miR-21 in CCC.
The results showed that the small GTPase, Rab35, is a direct functional target of miR-720 in cervical cancer HeLa cells.
