Sentence examples for be a direct downstream from inspiring English sources

CREB is presumed to be a direct downstream target of activated ERK [17].

The gene PIK3CA, which encodes the PI3K catalytic subunit, has previously been demonstrated to be a direct downstream target of transcription factor FOXO3a in CML [23], [24].

EphrinA7 has been shown to be a direct downstream target of Hoxa13 and Hoxd13 during limb development [ 90].

There was a concomitant decrease in total FLT3 as well as pSTAT5, described to be a direct downstream substrate of FLT3 in FLT3-ITD cell lines.

Taken together MCL-1 appears to be a direct downstream target of FL-stimulated FLT3 signaling as well as aberrantly activated FLT3-ITD in hematopoietic cells.

None of the NA markers (Phox2a, Hand2 or TH) has been shown to be a direct downstream target of Ascl1 (Castro et al., 2011), but they are upregulated sequentially during development (Howard, 2005; Rohrer, 2011).

Given that Myog is a direct downstream target of the myogenic activator protein MYOD136, we tested whether BET inhibition would be sufficient to prevent the activation of the myogenic program in fibroblasts undergoing MYOD1-mediated conversion to the myogenic lineage.

However, Dkk4 is a direct downstream target of Wnt [19], [20], [23], so that Dkk4 is not solely regulated by Eda.

Taking into consideration that SOC1 is a direct downstream target of CO [32], this observation also supports the notion that LOV1 acts upstream of CO and may act downstream or independently with GI.

Functional studies showed that the TESCO sequence was capable of acting as an enhancer in an Sry- and Sf1-dependent manner, consistent with Sox9 being a direct downstream target of Sry.

Taken together, these results suggest that ABCA3 is a direct downstream target gene of SALL4, and the expressions of two ABC genes, ABCA3 and ABCG2, are positively regulated by SALL4.