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Lupin flour revealed to be a difficult matrix, since large amounts of compounds tend to co-purify with DNA, even adopting well established extraction protocols.
Mustard proved to be a difficult matrix regarding precision.
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It should also be noted that our method deals with the inversion of a matrix, which might be a difficult task if the number of states is large.
Synovial fluid (SF) is a difficult biological matrix to analyse due to its complex non-Newtonian nature.
This is in accordance with the report of Verdon et al. [ 14], but Becker et al. deemed kidney to be a more difficult matrix [ 31].
Blood is a more difficult matrix to work with than urine, and collection of it is an invasive procedure.
Polymers are a quite difficult matrix to quantify additives by classical GC-MS due to the fact that a complex precipitation step has to be carried out to avoid injection of a higher fraction of oligomers into the GC injector causing analyte discrimination and carryover effects.
In general, calculation of an inverse matrix is a difficult method for solving an inverse problem numerically.
For an N-vertex sub-graph, the number of the node label permutation is N! In addition, there is a difficult problem using the associated matrix to store graphs, because an element represents both the connection relationship and orientation directly, such as "-1".
Determining an optimum design for these matrices is a difficult problem and is not pursued in this work.
Hematin plays a crucial role in various physiological functions, and the determination of hematin in complex biological matrixes is a significant but difficult issue.
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