APD is a difficult to treat disorder with the outcomes dependent on the underlying disease.
A deficiency or lack of corneal epithelium renewal due to limbal epithelial stem cell depletion or dysfunction results in the so-called limbal stem cell deficiency (LSCD) syndrome, which is a difficult and complex disorder to manage when it is complete and severe.
Selective mutism is a difficult and frustrating disorder.
Drug treatment of bipolar disorder is a difficult challenge due to the recurrent, episodic, and heterogeneous nature of the disease.
"If I'm able to use my voice to do good in the world then I definitely want to do that". Recovering from an eating disorder is a difficult task for anyone, and being in the public eye doesn't help.
On the other hand, the diagnostic yield of CNB for diagnosis of benignity was only 53%, confirming that a definitive diagnosis for a benign disorder is a difficult task.
Social Anxiety Disorder (SAD) is a difficult condition to battle, characterized by severe shyness, fear of other people, and occasionally an inability to speak in public.
Establishing animal models for psychiatric disorders, however, is a difficult task (Malkesman et al. 2009).
Posttraumatic stress disorder (PTSD) is a difficult-to-treat condition that over a lifetime affects approximately 10% of the general population [ 1].
However, this notation is difficult to use when there is a disorder within a disorder.
