There were only two differences: 1) PhoP was clustered into a different module, and 2) module 8 was disaggregated into two submodules.
The modular polyketide synthases are particularly amenable to this approach, because each cycle of chain extension is catalyzed by a different module of enzymes, and the modules are arranged within giant multienzyme subunits in the order in which they act.
(1) Conserved: both paralogs (UTP5 and UTP9 ) conserve the ancestral assignment (Module 1); (2) Neo-functionalization: one paralog (URA7 ) maintains the ancestral assignment (Module 1) and the other (URA8 ) is assigned to a different module (Module 5); (3) Asymmetric divergence: both paralogs (EUG1, PDI1 ) are reassigned to distinct modules (Module 3, Module 4) than the ancestral one (Module 5).
Sets of nodes are released in the sense that they are free to be re-allocated to a different module in subsequent executions of the MIQP model.
Further investigation of the overall network revealed that of these 142 unique phenotypes, only three shared only the Metabolic pathway in common; vWF, HA, and AF, although AF was located in a different module which consisted mainly of cardiovascular diseases.
We supposed that miRNA synergy can be dissected into two types: (a) the intra-modular regulatory effect of a miRNA pair upon the same biological process, i.e. participating in the same module and (b) the inter-modular regulatory effect of a miRNA pair upon multiple biological processes, i.e. each member of the pair is involved in a different module.
Overall, of all the paralog pairs that arose sporadically (not in the WGD) in the phylogeny, and where at least one member of the pair was subsequently reassigned to a different module, 53% do so 'at' the point at which they arose.
Steinberg: That's so right and we work with our clients on that where there might be 10 different modules to an offer but the system can auto choose, starting with everything from a subject line to what's the hero image is.
Inside the box are three different modules — a vital sensor, blood/urine strips and a smart scope.
As the counselling approach is a combination of different modules, hence a dismantling would be useful in further studies.
