Thus, we concluded that the dimer is a crystallization artifact and consider only the monomeric unit of the PHIST domain.
To confirm that oligomer formation is not a crystallization artifact, we treated mixtures of NaD1 and PIP2 in aqueous solution with the crosslinker BS, which resulted in covalent cross-linking of multiple NaD1 molecules that occurred only in the presence of PIP2, whereas NaD1 on its own only formed a dimer as reported previously (Lay et al., 2012).
Traditionally, the observation of higher order assemblies in crystals have been regarded as a crystallization artifact except if experiments also indicate their presence in solution.
The structures of the two PIR1 constructs are essentially identical (rmsd of ∼0.32 Å), and because there is no evidence of PIR1 oligomerization in solution, the trimeric arrangement seen in the orthorhombic crystal form may reflect a crystallization artifact.
It's a crystallization of a life that, in a crucial way, crystallizes Maysles's own artistic vision as well.
It's a crystallization of the idea that startups at different points in their lifecycles must make very different decisions.
That's a crystallization of China's security thinking, and it also goes along with the general thinking in Asia.
This might be a sample artifact.
Although this particular structural feature could be due to crystallization artifacts or intrinsic variability, we propose that molecular mechanisms at the basis of the enhanced interaction between Fc/3M and CD16 could include enhanced Fc openness as well as the introduction of additional hydrophobic contacts, hydrogen bonds and/or electrostatic interactions at the corresponding interface.
Finally, the left-handed helical filaments were crystallized at a lower pH solution [22], and it was suggested, therefore, that this conformation might be an artifact of this particular crystallization condition.
