Sentence examples for be a crucial initial from inspiring English sources

For many receptors, ligand-induced ubiquitination has been shown to be a crucial initial event in attenuation of receptor signaling [32], [33].

Quantitative structure activity relationship (QSAR) modelling, widely used for development of the biological and physical properties of new compounds, is a crucial initial step in lead optimization to correlate molecular structure with biological and pharmaceutical activities (Fig. 4).

Efficient identification of transcription factor binding sites is a crucial initial step in the study of gene regulation.

In conclusion, these results indicate that constitutive overexpression of the cyclinD1/cdk4 complex in RCS cells blocks FGF-induced p107 dephosphorylation and growth arrest, consistent with the hypotheses that p107 dephosphorylation is a crucial initial event in the response of chondrocytes to FGF signaling.

The coupling of ICAM-1 to LFA-1 is a crucial initial step to the recruitment of inflammatory cells to the vessel wall.

Analysis Finding functional modules of co-regulated genes during the course of development with an unsupervised learning method is a crucial initial step in the large scale analysis of developmental processes.

Aberrant IgA1 molecular with the glycans (galactose or sialic acid) deficiencies in the hinge region in circulation is deemed generally to be a crucial and initial factor for the development and pathological characteristics of IgAN [ 25- 28].

This is such a crucial initial point, the evidence has to be convincing.

Identifying these problems is therefore a crucial initial step when implementing comprehensive care for older patients with cancer.

Fluid resuscitation is a crucial component of initial resuscitation in major burn patients to avoid early mortality.

In Snake model, contour initialization is a crucial point; thus, if the initial contour is far from the target, it may not reach the target.