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Anti-cytokeratin antibody, known to be a consistent marker for conventional and chondroid chordoma [20], was used to label the tumor cells green (AlexaFluor 555, Figure 4, bottom panels) and to create a tumor specific mask within which red anti-PTEN signals were automatically quantitated (CY5, Figure 4, bottom panels).
Although cytokeratin 18 expression is now considered unreliable for differentiating between these lesions, brachyury, a transcription factor important in notochordal development, has been found to be a consistent marker for notochordal cell lesions [ 14, 17, 21, 22, 26].
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ProADM is a consistent marker of mortality risk and severity along time in severe sepsis and septic shock.
The presence of CB was a consistent marker of relapse in all classifications irrespective of whether patients with HAM or ORF were included or not.
If future controlled trials confirm that increased CMAP amplitude is a consistent marker of biologic response that correlates with improvement in motor function, then this outcome measure could prove a powerful surrogate biomarker for future clinical trials.
Rank, though, is a consistent marker of ill health.
Ltbp1L activity is a consistent marker of the ductal luminal lineage, appearing in the embryo at the first sign of ductal canalization.
Although H4K5ac and H4K12ac datasets could not be directly compared due to the different CFC training protocols used, the increase of both H4K5ac and H4K12ac immediately following CFC and the higher levels of H4K5ac after two training sessions, suggest that histone acetylation is a consistent marker of memory formation.
The dramatic and prolonged elevation of GFAP and Vim in demyelinated white matter, as well as in cortex with diverse injury models (i.e. MCAO and LPS), shows that up-regulation of these intermediate filament proteins is a consistent marker of reactive astrocyte phenotypes.
For instance, the expression of FOXP3 seems to be a more consistent marker for functional Treg in mice, than it is in humans [26] [28].
Since the reliability of Helios to identify nTreg cells has been questioned 33, we also stained cells for neuropilin 1 (Nrp-1), which has recently been shown to be a more consistent marker of this subset 34, 35.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com