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That was always going to be a considerable setback.
The absence of their captain would be a considerable setback for City given that they will also be without the suspended Yaya Touré and the latest bulletin on David Silva's knee injury indicates he might not be fully fit either.
Plainly, the alternative would be a considerable setback for Van Gaal given the consistently upward trajectory of De Gea's career since those early days in Manchester when he could be a danger to his own team and Eric Steele, then United's goalkeeping coach, talked of him being a poor trainer, "lazy" when it came to learning English, and eating "too many tacos".
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That was a considerable setback for an unelected, already unpopular President like Truman.
The enforced retirement of Ryan Harris is a considerable setback to Australia five days before the first Test, though it is not on the same scale as the injury to Glenn McGrath about 40 minutes before the start of the Edgbaston Test of 2005.
The figures are a considerable setback given the progress made since last year's border crisis, when agents apprehended about 68,000 unaccompanied minors along the border and about the same number of family units.
Aleksandr Zheleznyakov, a scientist with the Federation of Russian Cosmonautics, said the latest mishap was "a considerable blow to the industry's image, particularly taking into account our many setbacks in the last couple of years".
For Mr. Mugabe, 75, the only leader this nation of 12.5 million people has known since it achieved majority rule two decades ago, the defeat was regarded as a considerable setback, one certain to energize the growing opposition as the country prepares for parliamentary elections in April.
The American economy grew anemically during the spring, the government reported Friday, and prior growth was even slower than initially grasped, dealing a considerable setback to hopes for rapid improvement.
John Terry, nursing a sprained ankle, would probably not have started anyway, but Hazard's absence represents a considerable setback.
That is a considerable understatement.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com