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TSAHC emerged to be a competitive reversible inhibitor of mushroom tyrosinase.
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A-438079 is a competitive reversible inhibitor of the P2X7 receptor that is at least 100-fold more selective for this receptor than other members of the P2 receptor family (Donnelly-Roberts and Jarvis, 2007).
The glycine dependency of the IC50 values for TCN 213, the Schild analysis giving a unity slope and the fact that the antagonism can be surmounted and a maximum response retained by increasing the glycine concentration are consistent with the notion that TCN 213 is a competitive, reversible antagonist that acts at the GluN1 glycine binding site.
APA derivatives might be expected to have activity due to their potent inhibition of ODC, although a key difference between APA and DFMO relates to the fact that APA is a competitive reversible inhibitor of the enzyme while DFMO causes irreversible inactivation after covalently alkylating the enzyme's active site.
Cycloleucine is a competitive and reversible inhibitor of methionine adenosyltransferase (MAT), which catalyzes SAM synthesis during methionine metabolism [68].
However despite the importance of the simultaneous action of a suicide substrate and a competitive reversible inhibition, to date no corresponding kinetic analysis has been carried out.
GSK 2118436 is an ATP competitive, reversible inhibitor of the mutant BRAFV600E/K/D (IC50.6.5, 0.6, 1.9 n, respectively), wt BRAF (IC50 12 n) and CRAF (IC50 5 n) kinases with promising preclinical efficacy data in melanoma.
FAD has been used extensively in breast cancer research as a pharmaceutical inhibitor of aromatase and has been shown to be a reversible competitive inhibitor of aromatase in birds (Elbrecht and Smith 1992), mammals (Steele et al. 1987), and fish (Afonso et al. 1999, 2001).
Atosiban is a competitive inhibitor of the OXTR and blocks OXT-induced Ca2+ increase in myometrial cells in a reversible manner [ 60].
"He's a competitive guy.
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