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The blockade of AT2R led to an increase in ACE2 expression, which may be a compensatory response to the drastically increased inflammatory mediators and oxidative stress in the diabetic kidney.
We propose here that these parameters are linked, and suggest that soluble EZH2 that is released from spatial constraint may be a compensatory response to the loss of chromatin relocation capacity, enabling reinstatement of essential regulatory events, including the observed reinstatement of H3K27me3 at Xi in CIZ1 null cells.
In low-preload states, tachycardia may be a compensatory response to reduced cardiac preload to maintain cardiac output [24].
Our findings suggest that up-regulation of reelin may be a compensatory response to tau-related or beta-amyloid stress associated with AD even prior to the onset of dementia.
Thus, the up-regulation of spoT in the C. jejuni Δppk2 mutant may be a compensatory response to keep ppGpp levels low preventing cells from entering stress response.
It is possible that, the over-expression of SUMO-1 and SUMO-2, both of which are capable of adding SUMO to other proteins, in the testis of Sirt1 deficient mice may be a compensatory response to promote the sumoylation of specific proteins in the testis in the absence of the deacetylase activity of Sirt1.
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Alternatively, the decrease in goblet cells may have been a compensatory response to the increase in Paneth cells caused by Ap4 deletion.
Our studies identified a new pathway that drives the specification of glycolytic muscle metabolism and provided evidence suggesting that enhanced glycolytic metabolism is a compensatory response to elevated blood glucose levels in type 2 diabetes, and that inadequate adaptation of glycolytic metabolism may accelerate the progression of this disorder.
A tendency toward fibrinolysis is a compensatory response to prevent disseminated intravascular coagulation (DIC) which can result from shock.
Case [23], [53] speculated that gigantism in speckled rattlesnakes was a compensatory response to increased mass of its primary prey.
Further studies are warranted to determine whether elevated serum FGF-21 is causally related to dyslipidemia or is a compensatory response to CHD.
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