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Together these data suggest that low LigIII activity and SSB repair defects may be a common pathological mechanism of FUS-dependent ALS (schematically represented in Fig. 9).
Thymic involution has also been described in twitcher mice [21] and may therefore be a common pathological state among the LSDs.
Alterations in axonal transport are discussed to be a common pathological mechanism not only in several HSPs but also in other neurodegenerative diseases (34).
It also indicates that mtDNA damage might be a common pathological condition in a subgroup of FGD patients with defective responses to DNA damage [102].
Thus, the disruption of the TRPC3 signaling pathway might be a common pathological mechanism underlying cerebellar ataxia in mouse and human.
Taken together, along with additional research showing that pathologic TNF mediates neurotoxicity in the ischemic penumbra, these data suggest that chronic microglial activation and neuroinflammation may be a common pathological response to stroke and other forms of acute brain injury [ 86, 133– 133].
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Liver fibrosis is a common pathological response to chronic hepatic injury.
Protein aggregates are a common pathological feature of most neurodegenerative diseases (NDs).
Hepatic fibrosis is a common pathological basis of liver cirrhosis and hepatocellular carcinomas.
Liver fibrosis is a common pathological condition that occurs in most conditions associated with chronic liver injury.
Aggregates of mutant huntingtin are a common pathological marker in HD, meaning that they are present in cells affected by HD.
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