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Increasing evidence suggests that soluble aggregates-mediated toxicity might be a common pathogenesis mechanism for these disorders [18] [23].
Because TLR9 is highly expressed in DM [ 29- 31] and SLE [ 47], upregulated IL-6 production stimulated by PGRN via TLR9 may be a common pathogenesis of DM and SLE.
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Oxidative stress is a common pathogenesis of diabetes mellitus and asiatic acid (AA) plays an important role in ameliorating those difficulties.
Given that atherosclerosis is a common pathogenesis underlying the majority of CAD and stroke, our findings provide additional insight to understand the mechanistic basis of 9p21 on these clinical consequences.
Disruption in the Hip-PFC pathway, anatomically or functionally, might be a common element of pathogenesis in neuronal disorders and therefore underlies the curious overlap of symptoms among these otherwise disparate diseased conditions.
These observations indicate that deregulated expression of EEF1A2 might be a common contributor to the pathogenesis of mouse PCT and a subset of human MM in ways affecting disease initiation although contributions to progression are also possible.
The presence of Ub within inclusion bodies was noted in a large variety of neurodegenerative diseases [11] [14], suggesting that disruption of Ub homeostasis may be a common factor in the pathogenesis of these disorders; however, Ub has never been considered to be susceptible to aggregation.
Apolipoprotein E appears to be a common player in the pathogenesis of AS, SVD, and CAA.
Increased expression of DDR-2 may thus be a common event in the pathogenesis of OA in general [ 79].
Glutamate receptors are implicated in transformation to malignancy; it's hypothesized that glutamate receptors overexpression may be a common feature of tumor pathogenesis.
Prss23 is also up regulated in human FSGS patients, even when not caused by Cd2ap mutation, suggesting it may be a common feature of FSGS pathogenesis [ 35].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com