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Thus, the association of Crm1 with Hox loci could be a common molecular basis for aberrant Hox gene dysregulation mediated by numerous leukemic fusions.
Furthermore, the concept that association of Crm1 with Hox loci might be a common molecular basis for Hox gene dysregulation could be important.
As emergence of castration-resistance in PCa is invariably associated with highly aggressive and metastatic disease (Jennbacken et al, 2006; Srivastava et al, 2012), it appears that there may be a common molecular thread for these distinct phenotypes.
On a smaller set of samples, loss of TACSTD2 was identified in poorly differentiated SCCs of head-and-neck and esophageal tumors, indicating that the loss of TACSTD2 could be a common molecular event associated with SCC.
Thioester-dependent covalent adhesion may be a common molecular mechanism in host-microbe interactions, playing a key role in host colonization by both commensal and pathogenic Gram-positive bacteria.
As ACE inhibition has been shown to prevent AGE accumulation in diabetic tissues [ 50], it is feasible that inhibition of AGE formation could be a common molecular mechanism allowing both ACE inhibitors and aminoguanidine to inhibit the increase of retinal CTGF.
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Thus, the presentation of the PS signal is a common molecular mechanism functioning in a variety of biological processes.
Aberrant DNA methylation is a common molecular basis for a number of important human diseases, including breast cancer.
A wide variety of stem cells has been reported to exist and renew several adult tissues, raising the question of the existence of a stemness signature that is, a common molecular program of differentiation.
Covalent binding of xenobiotic electrophiles to nucleophilic endogenous biomolecules, e.g. peptides or DNA, is a common molecular initiating event, leading to potentially irreversible toxic effects such as enhanced acute toxicity, skin sensitisation, or mutagenicity.
The findings presented here provide strong evidence that mitotic recombination is a common molecular mechanism that results in an aUPD feature that occurs non-randomly in specific chromosomal locations, and that correlates with ER, PR and HER2/neu status of breast cancer and with homozygous mutation of specific genes.
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