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Renal tubulointerstitial fibrosis is considered to be a common final pathway related to the progressive loss of renal function in chronic kidney disease.
Accordingly, epithelial dysfunction may be a common final pathway contributing to organ dysfunction in sepsis and other forms of critical illness.
Intestinal epithelial dysfunction is believed to be a common final pathway contributing to organ dysfunction and mortality in sepsis (Fink, 2003).
Like pulmonary NTM, bronchiectasis is thought to be a common final manifestation of several conditions, including infectious causes as triggers of inflammation (22 ).
Thus, there appears to be a common final pathway for multiple forms of familial and sporadic ALS, wherein cytosolic accumulation of aggregated proteins, whether via a primary enhancement of aggregate formation or via defects in autophagy or the UPS, creates an environment that promotes neurodegeneration.
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Factors weakly associated with instructor reports of lack of time were a common final and reporting that approximately half of the students lacked the ability to succeed in the course.
Photoreceptor apoptosis is a common final path of many inherited and induced retinal neurodegenerations.
Tubulointerstitial fibrosis is a common final pathway for end-stage renal diseases, including diabetic nephropathy.
In summary, tubulointerstitial fibrosis is a common final pathway of CAN.
Furthermore, pneumonia is a common final pathway to death, which in most occasions was not suitable as the underlying COD.
Sepsis-induced multiple organ system failure is a common final pathway believed to be caused by a systemic inflammatory response involving micro- and macro-circulatory dysfunction and alterations in cellular metabolism, particularly mitochondrial dysfunction, though the exact mechanisms remain unknown [ 3– 5].
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