This must be a common event.
In addition, CYP21A2 gene duplications with one of the copies mutated have been found to be a common event.
These results suggest that the negative regulation of HSP70 expression by AMPK might be a common event under stress.
H2O2 production within nuclei occurs due to oxidative demethylation of histones [46], and stimulation of oxidant production appears to be a common event associated with DNA damage and repair [47].
The presence of PHD3 promoter hypermethylation and PHD3 silencing in such a wide range of cancer types suggests this might be a common event that elicits a selective advantage for tumors.
Since transcription generally continues through S-phase, while DNA is being replicated, the collision of the transcriptional machinery and stalled replication forks is thought to be a common event [60].
In many TRAIL resistant breast and ovarian cancer cell lines but not sensitive cell lines, the Akt pathway was activated (Fig. 2), suggesting that the activation of the Akt pathway may be a common event in TRAIL resistant cells.
This detailed analysis at the complete genome level demonstrates that recombination may be a common event within adenoviruses, especially in species HAdV-D, as a general mechanism driving molecular evolution and immunogenicity.
Interestingly, even though either N-Myc or c-Myc are expressed in most if not all proliferating cell types [42], [27], they are rarely expressed in the same cells and switching from expression of one Myc gene to another appears to be a common event associated with various developmental transitions during organogenesis and in homeostatic tissues [37].
