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These results suggest that mRNA oxidation may be a common early event preceding motor neuron degeneration in ALS.
Patellofemoral osteoarthritis (PFOA) is increasingly recognised to be a common, early form of knee OA in middle and old age, associated with symptoms and functional limitation [ 1].
Thus, increased CAD expression may be a common early plant response to pathogens, presumably leading to increased deposition of lignin, suberin and callose into the cell wall to strengthen barriers against further pathogen ingress.
6 7 Dysphagia was identified in another primary care study as an independent predictor of PDAC in men, 6 however it was not found to be a common early symptom in this study.
Shortly after these discoveries, it was found that let-7 expression resulted in a significant decrease in lung cancer cell-line growth, indicating that let-7 plays an important role in controlling cellular growth in cancer cells [ 68]. let-7 downregulation also appears to be a common early event in the progression of ovarian cancer [ 70- 77].
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This was a common early reaction to the sedative for little ones.
A few studies have demonstrated that a transient change in Ca2+ permeability of the plasma membrane is a common early event key to plant defense signaling [78].
A net K+ eflux in elicitor treated cells is a common early response [ 26].
Acute kidney injury (AKI) is a common, early and severe organ dysfunction during sepsis [ 1].
Autonomic neuropathy, altered cardiac vagal response in particular, is a common early feature of diabetes (10).
DNA methylation is a common early event in carcino-genesis and can be a potential predictor of cancer risk.
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