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Already shown to be a clinically viable means of reducing gene expression in a number of other diseases, therapies based on RNA interference (RNAi) can directly target hepatitis B virus transcripts with high specificity, profoundly reducing the production of viral proteins.
The successful approval of the effector function modulated mAbs eculizumab, obinutuzumab, and mogamulizumab has demonstrated that altering effector function can be a clinically viable way to differentiate mAbs from standard human IgG subclasses.
Screening for reduced AMPK protein expression may be a clinically viable means to predict metabolic hypersensitivity in tumours.
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Lamotrigine (LTG) is a clinically viable option to treat epilepsy and bipolar disorder in pregnant women 1, 2 in large part due to low relative risks of teratogenic complications and adverse neurodevelopmental effects compared to other medication options.
Adipose-derived stem cells (ASCs) are a clinically viable alternative to SC. SC-like differentiated ASCs (dASC) express glial markers and growth factors, produce myelin, induce neurites outgrowth in vitro and promote nerve regeneration in vivo.
Peptides are not a clinically viable therapeutic option resulting from problems associated with the development of autoimmunity.
The protocol can be adapted to be used on a clinically viable timescale without any detrimental effect on the quality of the data, which is crucial if it is to be used on patients.
RNA aptamer technology targeting OPN may represent a clinically viable therapy.
In particular, maximising the after-effects will be particularly important if non-invasive treatments are to be clinically viable in dementia populations, and help minimise the number of treatment sessions needed to obtain meaningful symptom improvements.
In all, this study suggests that research in cortically-controlled prosthetic systems may require reprioritization to achieve performance that is acceptable for a clinically viable human system.
In summary, mEHT is more effective in combined immunotherapy than is conventional hyperthermia in a clinically viable temperature range.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com