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Given these results and other advantages of adipose derived stem cells such as ease of harvest and relative abundance, dASC could be a clinically translatable route towards new methods to enhance peripheral nerve repair.
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Together, these data suggest that scaffolds which persist throughout the remodeling phase of repair may represent a clinically translatable method to prevent HSc contraction.
Quantitation of tumour ADC thus appears to be an attractive, clinically translatable imaging biomarker sensitive to therapeutic response to HIF-pathway inhibition.
This study indicates that a clinically translatable strategy of engineering the DC content of grafts can improve clinical outcomes in allogeneic HSCT through the regulation of donor T cell activation and GVL activity.
Therefore, we consider the proof-of-concept of fusion of technologies used here offers high potential as a clinically translatable genetic modification strategy for cell therapy.
In summary, the combination of hDAM and hASCs provides not only a clinically translatable platform for adipose tissue engineering, but also a vehicle for elucidating fat grafting mechanisms.
DMM comprising muscle and fascia ECM as a whole unit can thus provide not only a clinically translatable platform for musculofascial tissue repair and regeneration but also a useful standard for scaffold design in musculofascial tissue engineering.
CrT activation may become a clinically translatable target for anti-ischaemic therapy.
For the first time, utilizing a clinically translatable animal model of high-risk metastatic neuroblastoma, we have identified the cluster of metastamiRs, their functional translation in terms of target protein expression, and the association of such alterations with clinical outcomes.
However, the disappointment of negative results must be weighed against the benefit of being able to refocus efforts on drugs, which are more likely to be clinically translatable.
This is a clinically significant finding.
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