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However, a randomised trial [ 17] comparing early use of EXOGEN (at 3 months) and observation followed by surgery (if needed at 9 months) was available, and this was thought to be a clinically appropriate comparison in the NHS.
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Today's guidance means that where surgery is a clinically appropriate way of managing heavy menstrual bleeding, women can choose from a wider range of alternative treatments".
This manuscript sheds light on the likelihood that a generic medication is a clinically appropriate substitute.
However, for cognitive performance to become a consideration in clinicians' and patients' choice of drugs, robust cognitive effects must be seen when drugs are administered at a clinically appropriate dose, rather than at a dose dictated by solely by a research protocol.
The family had to raise over £27,000 for the operation to be done within a clinically appropriate timeframe.
The study was conducted in a clinically appropriate cohort of patients for the dose of FF/VI used and was sufficiently long to allow clinically meaningful conclusions to be drawn from the data.
A total of 54 brackets were bonded in a clinically appropriate position, with the slot at the halfway point of the clinical crown, using a cyanoacrylate adhesive.
The aim of this study is to develop a clinically appropriate outcome prediction tool based on measurable predictors affecting outcome.
Stanbury laid out those biochemical interests in some detail; by contrast, his comments on the agenda of the Department of Health and Social Services (DHSS) seem an afterthought: "obviously it is fully appreciated that the primary purpose of any DHSS supported survey would be the compilation of a clinically appropriate questionnaire and system of physical examination".
All materials were set up in a clinically appropriate fashion for the participants beforehand, unlike in a real resuscitation.
Unfortunately these criteria deal mainly with technical issues and make no approach to determining clinical quality (e.g., whether a clinically appropriate comparator is chosen, whether the enrolled population is appropriate, and duration of follow-up) (Table 3).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com