Sentence examples for be a central mediator from inspiring English sources

In fact, JNK signalling appears to be a central mediator of many of the cell-autonomous phenotypes observed in dVps4-deficient cells.

In fact, p38 appears to be a central mediator of L-selectin shedding induced by various stimuli.

TNF-α is believed to be a central mediator of muscle wasting in rheumatoid arthritis by alteration of the balance between muscle protein synthesis and breakdown.

Hepcidin could be a central mediator of decreased iron absorption through the gut and of sequestration of iron in macrophages, and its structure has also shown homology to naturally occurring antimicrobial proteins [ 14].

Moreover, TNF-α which is believed to be a central mediator of muscle wasting in RA exerts a powerful influence on muscle protein turnover resulting in a net muscle protein wasting [ 18, 19].

Increased AMP (or ADP) to ATP ratios stimulate AMP-activated protein kinase (AMPK), which is known to be a central mediator of cellular metabolism in eukaryotes (Mihaylova & Shaw, 2011).

Like E-selectin, P-selectin is a central mediator of leukocyte rolling during inflammation and is also able to mediate the adherence of platelets to neutrophils and monocytes [ 11], allowing this molecule to participate in the cross-talk between the inflammatory and thrombogenic processes.

Zhao P, Xu Y, Wei Y, Qiu Q, Chew T-L, Kang Y, et al. The CD44s splice isoform is a central mediator for invadopodia activity.

Transcription factor Foxn1 is a central mediator of the differentiation and function of TEC.

NF-κB is a central mediator of pro-inflammatory gene induction and functions in both innate and adaptive immune cells.

Davalos, A.R. et al. p53-dependent release of alarmin HMGB1 is a central mediator of senescent phenotypes.