Sentence examples for be a central effector from inspiring English sources

LMP-1 acts as a constitutively active, receptor-like molecule that does not need the binding of a ligand [7], and appears to be a central effector of altered cell growth, survival, adhesive, invasive and antiviral potential [8], [9], [10], [11], [12], [13], [14].

Interestingly, NF-κB was also found to be a central effector molecule at the early and late time points of STAT3-independent transformation-regulated genes (Additional file 1: Figure S10C, D).

Although BAX may be a central effector of its proposed transcriptional regulator, the tumour suppressor gene p53 (Miyashita and Reed, 1995), we found, consistent with the results of others (Watanabe et al, 2001), no significant correlation between p53 protein expression alone and outcome in our series.

Caspase-3 is a cysteine protease located in both the cytoplasm and mitochondrial intermembrane space that is a central effector of many apoptotic pathways.

Since AID is a central effector in both IgH CSR and SHM [11], [12], and errors (oncogene translocation and/or mutation) in these processes lead to the development of NHL, the induction of AID expression has the potential to play a seminal role in the genesis of these cancers.

The SH2 domain-containing leukocyte adaptor protein of 65 kDa (SLP-65) is a central effector for signaling downstream of the B-cell antigen receptor (BCR).

The transcription factor encoded by Smad4 is a central effector of the transforming growth factor beta 1 (TGFβ1) signaling pathway [ 12], which is one of the 12 core signaling pathways reported to be altered in most PDAC cases [ 13].

OPN is an extracellular matrix glycophosphoprotein implicated in osteoblast differentiation [45] but is also a central effector of vitamin D – mediated anchorage-independent growth [68].

We hypothesize that redox modulation, whether by MDSC, dendritic cells or Tregs, may be a central theme in the regulation of effector T cell function by regulatory immune subsets in a variety of circumstances.

Nonetheless, in addition to being a cell death effector mechanism, autophagy appears to be a central component in influencing how breast cancer cells die in response to antiestrogens.

Since our previous work in the whole heart consequent to infarction of the left anterior descending coronary artery demonstrated that JNK signal transduction is a central downstream effector pathway of the ligand-RAGE axis during ischemia/reperfusion, we sought to determine the effect of this pathway in isolated adult cardiomyocytes exposed to H/R.