And they agreed that cutting emissions might be so expensive that the treaty should allow countries innovative, flexible approaches to reduce compliance costs.This last point is a central bone of contention in The Hague.
Whether love involves some kind of identification, and if so exactly how to understand such identification, is a central bone of contention among the various analyses of love.
The ability of GH to activate ERK in MSCs may therefore be a central control mechanism underlying bone development and growth.
To date, several cell lines of evidence have shown that, among various integrins, osteoclasts express very high levels of integrin αVβ3 and it is now well accepted that this integrin is a central molecule for osteoclastic bone resorption [ 23].
Finally, multiple lines of evidence suggest that central neural control, integrally regulates aspects of bone marrow function and immunological response [71], [72] and a number of studies have established that there is a central control mechanism that regulates bone remodeling [73], [74].
Erosion of periarticular bone is a central feature of RA and psoriatic arthritis [ 5, 6].
The thymus is a central lymphoid organ, in which bone marrow-derived T cell precursors undergo a complex process of maturation.
The thymus is a central lymphoid organ, in which bone marrow-derived T cell precursors undergo a complex process of maturation, eventually leading to the migration of positively selected thymocytes to the T-dependent areas of peripheral lymphoid organs.
As with bone tumor pathogenesis, a pathologically increased bone metabolism is a central feature of chronic arthritis, resulting in functional disorders of the joints [ 12].
Finally, we propose that the bone marrow is a central organ in mature T-cell traffic and contributes greatly to long-term cytotoxic memory, which has implications for adoptive immunotherapy and vaccine design.
