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The acute-phase protein HSP70 has been reported to be a cell mediator reacting to bacterial, viral and parasitic pathogens [ 27, 28].
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For example, RACK1 was first found to be a mediator of cell spreading by establishing contact with the extracellular matrix and growth factor receptors at adhesion sites [ 76].
However, strikingly, dinJ-yafQ seems to be a principal mediator of cell death in biofilm formation (Figures 3 and 4).
relBE seems to be a principal mediator of cell death only in liquid media (Figure 2, [30]), but not in biofilm formation (Figure 3).
Of these, USP9X is a well-characterized gene that has been shown to be a critical mediator of cell survival.
RHAMM appears to be a key mediator of fibroblastoid cell functions.
A decline in proteostasis has been proposed to be a critical mediator of the cell and tissue deterioration that is the characteristic of ageing.
These results indicate that PI3K/Akt pathway may be a specific mediator of integrin-dependent cell attachment in OCUM-2MD3 cells.
Finally, the differential expression of αvβ3 and α5β1 integrins in engineered cell lines was found to be an important mediator of cell sensing of the nanoscale geometry of the ECM.
Rgs2 inhibits cell proliferation, and is a known mediator of cell differentiation in several cell types, such as myeloid cells [18].
Voltage-dependent anion channel (VDAC) has been suggested to be a mediator of mitochondrial-dependent cell death induced by Ca2+ overload, oxidative stress and Bax-Bid activation.
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