Sentence examples for be a causal variant from inspiring English sources

These findings indicate the biological mechanism(s) that potentially underlie the role of this non-protein-coding risk variant, and indicated that rs6983267 may be a causal variant for the susceptibility to CRC.

These observations suggest that rs4149056 is unlikely to be a causal variant of the observed association for rs7489119.

Alternatively, there may be a causal variant residing on or near the corresponding haplotype that affects the risk of PCa development.

At ABCG2, the rs2231142 variant (Q141K), which is highly likely to be a causal variant at this locus [ 36], was associated with ABCG2 expression in the liver [ 4].

The existence of multiple highly correlated variants (some of which have potential functional significance) which are all associated with disease risk raises the question as to which, if any, of these might be a causal variant and thus driving the association at this locus.

Along with previous functional data our finding increases the confidence that the promoter polymorphism is a causal variant.

We wish to report that this statement may cause readers to conclude erroneously that rs34861192, but not rs1862513 (SNP-420C>G), is a causal variant determining circulating resistin.

If an observed genetic association is true, then it implies that either the investigated variant is causal (direct association) or there is a causal variant in linkage disequilibrium with the investigated one in its neighborhood (indirect association).

We cannot speculate whether rs7715300 is a causal variant itself, or it is in LD with a marker within any of the two genes (however no SNP within the two genes is in high r2 with rs7715300).

Instead we use a simulation procedure (see below) to precompute the metric that is used to select the partner SNP in such a way that higher scores are assigned to correlation patterns that tend to lead to higher significance for the AI test than for single-SNP testing, when there is a causal variant in the vicinity of the two SNPs.

These results suggest that there could be a causal associated variant correlated with both rs10995190 and rs16917302, or alternatively more than one causal disease variant in this locus.