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Exposure to UV radiation is thought to be a causal event in at least 80% of the malignant melanoma cases [63], [64].
Along with these studies, our finding that Ang II-infusion induced platelet-leukocyte conjugation could be a causal event for initiation of cardiac inflammation.
Peroxisome proliferation per se does not appear to be a causal event in liver carcinogenesis (Melnick 2001) and therefore may not be a reliable marker for evaluating human cancer risk.
Thus, it is possible that Crym may be involved in striatal vulnerability through two possible ways: reduction of Crym expression could be a causal event leading to death/dysfunction, pointing to Crym as a neuroprotective/pro-survival protein.
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The finding that RXPO3R, a specific inhibitor of MMPs, essentially mimicked the effects of TIMP-1 provides indirect evidence that TIMP-1 targeting of MMPs is a causal event.
The dynamic process of epithelial-to-mesenchymal transition (EMT) is a causal event in kidney fibrosis.
Epigenetic silencing by promoter methylation and chromatin remodelling affects hundreds of genes and is a causal event for lung cancer.
Promoter hypermethylation is a causal event for long-term repression of BVES and POPDC3, whereas EGF stimulation is an immediate repression mechanism for both genes in gastric cancer.
hPrP90-231-FITC intraccumulationcumulation was correlated with the detection of apoptosis, suggesting that lysosomal overloading is a causal event in SH-SY5Y cell death.
Epigenetic-mediated silencing of genes by cytosine DNA methylation in CpG islands localised in promoter regions and chromatin remodelling involving the recruitment of transcriptional corepressors and modification of histone tails is a causal event for the initiation and progression of lung cancer (Jones and Baylin, 2002; Herman and Baylin, 2003).
The elevation of oxidized proteins levels during RT might be a causal factor in an early event of oxidative endothelial cell damage and also a marker of enhanced RT-related oxidative stress [ 53].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com