Doing so would be a big setback for a company that says its mission is "to organize the world's information and make it universally accessible and useful".
A failure by China to meet its own energy efficiency targets would be a big setback for international efforts to limit such emissions.
Experts argue that if the treaty ends without agreement or with a weak document, it will be a big setback for Mr. Obama's goals.
The higher tariff, if it sticks, would be a big setback for Perdue, for this is a market to make an agribusiness giant salivate.
"If it doesn't happen it will be a big setback for Brazil in terms of revenue, and a significant loss for the world in terms of new oil supplies".
If the talks fail, it will be a big setback for African leaders who have tried to end the ruinous four-year war and refocus attention on an economic plan to rebuild Africa.
Should Brazil officially reject biotechnology's lure, it would be a big setback for American companies that have already been hurt financially by fierce resistance in Europe from consumers and large companies that refuse to buy modified produce.
Mr Cameron risked setting in motion "an uncontrollable dynamic" leading to British exit, which would be a "big setback" for the EU but "a veritable disaster" for the British.Many in Europe share Mr Cameron's desire for a deeper single market, less intrusive regulation, less bureaucracy and a rejigging of powers between Brussels and national capitals.
Greenland told me, "Somebody actually said on a Web site, 'I hope this novel lives up to all the hype, because if not, it's going to be a big setback for all fantastic historical crossover writers".' He raised his eyebrows, waiting for me to complete the joke.
They're hungry, they want it and it won't be a big setback for them".
